陈曦 教授、硕/博导
Professor Xi CHEN
Email：chenxi@ecust.edu.cn
所属组室：教育部医用生物材料工程研究中心
办公地点：徐汇校区新材料大楼
教育背景 Education
本科(2009）材料科学与工程，吉林大学
硕士(2012）材料科学与工程，清华大学
博士(2016）化学与生物分子工程，墨尔本大学
工作经历 Work Experience
博士后（2016-2017）美国加州大学洛杉矶分校
博士后（2017-2019）美国哈佛大学
副教授（2019-2025）304am永利集团官网/304am永利集团官网
教 授（2025 - 至今）304am永利集团官网/304am永利集团官网
主要学术/社会兼职 Part-time Job
中国生物材料学会神经修复材料分会青年交流委员会/副主任委员
国际华人骨研学会/终身会员
上海市科普志愿者协会《院士专家科学诠释者指导团》/青年科普专家
教学课程 Teaching
本科生《生物材料》（上海市重点课程）
研究生《纳米材料毒理学与安全性》《生物医学工程前沿进展》
卓越工程师《生物材料与再生医学工程》（校一流研究生课程）
研究方向 Research Interests
功能化细胞外基质材料构建及其促神经再生机制研究
骨靶向纳米材料构建及其生物学效应研究
材料生物学研究新技术与新方法，如：器官芯片与类器官、超高分辨显微镜等
主要科研项目 Research Funding
国家自然科学基金委员会, 面上项目，2024.01-2027.12，主持
国家重点研发计划项目，2022.11-2025.10，子课题负责人
中央高校基本科研业务费项目，2022.01-2022.12，主持
国家自然科学基金委员会，青年项目，2022.01-2024.12，主持
中央高校基本科研业务费项目，2021.01-2021.12，主持
学生培养 & 招生专业 Student Recruitment
自2020年以来，指导博士生6名，研究生10余名；其中1名研究生获得国家奖学金、上海市优秀毕业生；1名获304am永利集团官网优秀毕业生；7名研究生获校一等奖学金
招收专业：材料科学与工程（学硕）、生物医学工程（学硕）、材料工程/材料与化工（专硕）。课题组每年招收1名博士生，3-6名硕士生，欢迎对生物材料感兴趣的同学，将个人简历发至邮箱，包括所获奖励、报考分数、成绩单等。To prospective students, please contact chenxi@ecust.edu.cn for more information
入职华理后发表的学术论文 Publications@Ecust
18. Sixu Zhang, Sixian Zhang, Wenwen Fan, Changsheng Liu, Xi Chen*. Promoting ROS scavenging and osteogenic differentiation by metal–phenolic network nanoparticle-embedded microenvironment-responsive hydrogel for the repair of senile osteoporotic bone defects. Journal of Materials Chemistry B 2025, 13, 10043
17. Yuexin Wang, Shu Chen, Sixian Zhang, Wenwen Fan, Xi Chen*. Cell ratio-dependent osteoblast–endothelial cell crosstalk ing osteogenesis–angiogenesis coupling via regulation of microfluidic perfusion and paracrine signaling. Micromachine 2025, 16, 539
16. Bixue Wang, Qiya Zhang, Changsheng Liu*, Xi Chen*. Counteracting immunodepression by extracellular matrix hydrogel to e brain tissue remodeling and neurological function recovery after traumatic brain injury. Biomaterials 2025, 318, 123181
15. Xi Chen, Yuan Yuan, Yeqiang Tan*, Changsheng Liu*. Strategic study on the development of inorganic non-metallic biomaterials. 无机材料学报 2025, 40, 449
14. Xi Chen*, Weihui Wu, Wei Zhu, Jiajing Zhou, Jingqu Chen, Zhixing Lin, Sixian Zhang, Frank Caruso*, Changsheng Liu*. Regulation of bone remodeling by metal–phenolic networks for the treatment of systemic osteoporosis. ACS Applied Materials & Interfaces 2025, 17, 4, 5995
13. Ruijia Yan, Shu Chen, Bixue Wang, Changsheng Liu, Xi Chen*. Magnetic field-oriented conductive decellularized extracellular matrix hydrogel synergizes with electrical stimulation to e spinal cord injury repair and electrophysiological function restoration. Biomaterials Advances 2025, 169, 214169
12. Zhiqiang Tai, Jiashang Liu, Bixue Wang, Shu Chen, Changsheng Liu, Xi Chen*. The effect of aligned and random electrospun fibers derived from porcine decellularized ECM on mesenchymal stem cell-based treatments for spinal cord injury. Bioengineering 2024, 11, 772
11. Jiashang Liu, Ruijia Yan, Bixue Wang, Shu Chen, Hua Hong, Changsheng Liu, Xi Chen* Decellularized extracellular matrix enriched with GDNF enhances neurogenesis and remyelination for improved motor recovery after spinal cord injury. Acta Biomaterialia 2024, 180, 308
10. Ying Wang, Fangru Xie, Zirui He, Lingbin Che, Xi Chen*, Yuan Yuan*, Changsheng Liu*. Senescence targeted and NAD dependent SIRT1 activated nanoplatform to counteract stem cell senescence for ing aged bone regeneration. Small 2024, 20, 2304433
9. Zirui He, Chuanhao Sun, Yifan Ma, Xi Chen, Ying Wang, Kai Chen, Fangru Xie, Yan Zhang, Yuan Yuan*, Changsheng Liu*. Rejuvenating aged bone repair through multihierarchy reactive oxygen species-regulated hydrogel. Advanced Materials 2024, 36, 9
8．Ying Wang, Lingbin Che, Xi Chen, Zirui He, Dianwen Song*, Yuan Yuan*, Changsheng Liu*. Repurpose dasatinib and quercetin: Targeting senescent cells ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration. Bioactive Materials 2023,25,13
7．Shuaimin Tang, Dongyong Sha, Zirui He, Xi Chen, Yifan Ma*, Changsheng Liu*, Yuan Yuan*. Environmentally adaptable organo–ionic gel-based electrodes for real-time on-skin electrocardiography monitoring. Advanced Healthcare Materials 2023,12, 2300475
6．Xuewei Zhang, Bixue Wang, Hua Hong, Ying Wang, Jiashang Liu, Changsheng Liu*, Xi Chen*. Decellularized extracellular matrix and mesenchymal stem cells e recovery in traumatic brain injury by synergistically enhancing neurogenesis and attenuating neuroinflammation. Journal of Materials Science & Technology 2023, 138, 17
5．Xiaolong Zhan#, Zhengbo Wen#, Xi Chen*, Qi Lei, Yuxin Chen, Liang Zhou, Guansheng Zheng, Fanhui Kong, Jimin Guo, Yuyou Duan, Yuyan Lai, Panchao Yin, C. Jeffrey Brinker, Honglin Chen*; Wei Zhu*. Polyphenol-mediated biomimetic mineralization of sacrificial metal-organic framework nanoparticles for wound healing. Cell Reports Physical Science 2022, 3, 101103
4．Xi Chen, Shuyan Han, Weihui Wu, Zihan Wu, Yuan Yuan*, Jun Wu*, Changsheng Liu. Harnessing 4D printing bioscaffolds for advanced orthopedics. Small 2022, 18, 2106824
3．Xuewei Zhang, Xi Chen*, Hua Hong, Rubei Hu, Jiashang Liu, ChangshengLiu*. Decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering. Bioactive Materials 2022, 10,15
2．Xi Chen*, Yu Wang, Xuewei Zhang，and Changsheng Liu*. Advances in super-resolution fluorescence microscopy for the study of nano–cell interactions. Biomaterials Science 2021, 9, 5484
1．Xi Chen*, Yu Shrike Zhang, Xinping Zhang, Changsheng Liu*. Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine. Bioactive Materials 2021, 6,1012